Prognostic significance of serum B-lymphocyte stimulator level in Hodgkin's lymphoma

Y. Oki, G. V. Georgakis, T.-S. Migone, L. W. Kwak, A. Younes
2007 Haematologica  
B-lymphocyte stimulator (BLyS) plays a critical role in the survival of B-lymphocytes. In 50 patients with Hodgkin's lymphoma BLyS levels were higher in newly diagnosed patients (median 2.0 ng/mL, range <0.3-56.0) and relapsed patients (8.7 ng/mL, range 1.5-71.5) than in 93 healthy donors (<0.3 ng/mL, range <0.3-0.5). High serum BLyS levels (≥ ≥2.0 ng/mL) in newly diagnosed patients were associated with resistance to therapy (p=0.01) and shorter progression-free survival (log-rank p=0.029,
more » ... -rank p=0.029, 2-year rate 64% vs 100%). Serum BLyS levels may have prognostic significance in Hodgkin's lymphoma. Haematologica 2007; 92: 269-270
doi:10.3324/haematol.10678 pmid:17296586 fatcat:k3gtsrxhvrfzpdryg53e46lxii