A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2017; you can also visit the original URL.
The file type is
A series of pyrrolo [2,3-d]pyridazinones was synthesized and tested for their inhibitory activity on PDE4 subtypes A, B and D and selectivity toward Rolipram high affinity binding site (HARBS). New agents with interesting profile were reported; in particular compound 9e showed a good PDE4 subtype selectivity, being 8 times more potent (IC 50 ¼ 0.32 mM) for PDE4B (anti-inflammatory) than for PDE4D (IC 50 ¼ 2.5 mM), generally considered the subtype responsible for emesis. Moreover the ratiodoi:10.1080/14756360601114700 pmid:17674813 fatcat:rpa2bjms2zf3faatc4k4xtxiwi