Issues in the Reconstruction of Gene Order Evolution

David Sankoff, Chunfang Zheng, Adriana Muñoz, Zhenyu Yang, Zaky Adam, Robert Warren, Vicky Choi, Qian Zhu
<span title="">2010</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="" style="color: black;">Journal of Computer Science and Technology</a> </i> &nbsp;
As genomes evolve over hundreds of millions years, the chromosomes become rearranged, with segments of some chromosomes inverted, while other chromosomes reciprocally exchange chunks from their ends. These rearrangements lead to the scrambling of the elements of one genome with respect to another descended from a common ancestor. Multidisciplinary work undertakes to mathematically model these processes and to develop statistical analyses and mathematical algorithms to understand the scrambling
more &raquo; ... n the chromosomes of two or more related genomes. A major focus is the reconstruction of the gene order of the ancestral genomes.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="">doi:10.1007/s11390-010-9301-9</a> <a target="_blank" rel="external noopener" href="">fatcat:x7mt6guq2naktbpre6bogfugmy</a> </span>
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