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Multiplex proteomics using isobaric labeling tags has emerged as a powerful tool for the simultaneous relative quantification of peptides and proteins across multiple experimental conditions. However, the quantitative accuracy of the approach is largely compromised by a phenomenon termed ion interference, causing fold changes to appear compressed. The degree of compression is generally unclear, and the contributing factors are poorly understood. In this study, we thoroughly characterize iondoi:10.1101/2022.06.24.497446 fatcat:xl2ushocqfexjkdcrnp4q2q6ey