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Human serine racemase structure/activity relationship studies provide mechanistic insight and point to position 84 as a hot spot for β-elimination function
2017
Journal of Biological Chemistry
There is currently great interest in human serine racemase, the enzyme responsible for producing the NMDA co-agonist D-serine. Reported correlation of D-serine levels with disorders including Alzheimer's disease, ALS, and ischemic brain damage (elevated D-serine) and schizophrenia (reduced D-serine) has further piqued this interest. Reported here is a structure/activity relationship study of position Ser 84 , the putative re-face base. In the most extreme case of functional reprogramming, the
doi:10.1074/jbc.m117.777904
pmid:28696262
pmcid:PMC5572919
fatcat:bgvs6lyoenafxdonadcmphf2zi