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Proceedings of The Japanese Society of Animal Models for Human Diseases
In order to define the role of steel factor encoded by the mouse steel (Sl) gene in spermatogenesis, we have examined its production in Sertoli cells. The ability to support proliferation and maintenance of mast cells in co-culture with primary mouse Sertoli cells were used for steel factor bioactivity. Sertoli cells derived from +/+ and Wv/Wv but not Sid/Sid mutant mice produce biologically active steel factor as a membrane-bound form. Testicular cells prepared from neonatal (2 days and 5 daysdoi:10.1538/expanim1992.9.15 fatcat:224ziszernftli5pol6g5vy7ca