Benefit of Glycemic Control for Reducing the Effects of Air Pollution on Blood Pressure: A Panel Study

Youn Hee Lim
2014 Journal of Diabetes & Metabolism  
Objective: Diabetes mellitus (DM) is known to aggravate the association between air pollution and cardiovascular diseases, such as hypertension. However, the influence may differ based on the degree of glycemic control. Therefore, we hypothesized that the adverse effects of air pollutants on Blood Pressure (BP) in patients with controlled DM would be less than those in patients with uncontrolled DM. Methods: Data were analyzed from a panel study of 560 elderly participants, conducted between
more » ... 8 and 2010 in Seoul, Korea. Mixed effects models were used to assess the association of air pollutants [particulate matter with aerodynamic diameters<10 μm (PM 10 ), PM 2.5 , PM 10-2.5 , nitrogen dioxide, ozone, sulfur dioxide, and carbon monoxide] with BP. We compared the magnitude of the effects among individuals with controlled and uncontrolled DM and those without DM. Results: Increases in the interquartile range levels of PM 10 were significantly associated with 2.0 mmHg (95% CI, 0.7-41.7 mmHg) increases in systolic BP (SBP) and 2.0 mmHg (95% CI, 1.2-41.7 mmHg) increases in diastolic BP (DBP) when we analyzed all participants. Most of the other air pollutants, except ozone, were also associated with significant increases in BP. When we compared the BP changes among the three groups (non-DM, controlled DM, and uncontrolled DM), significant increases in SBP and DBP were observed in participants with uncontrolled DM and those without DM; significant BP increases were not observed in participants with controlled DM. Conclusion: Glycemic control provided benefits for alleviating BP changes associated with exposure to air pollutants. previously reported to be affected by the exposure to air pollutants [11] [12] [13] [14] [15] . We hypothesized that the adverse effects of air pollutants on SBP and DBP would be less in patients with controlled DM than in those with uncontrolled DM or, possibly, in non-DM individuals. Materials and Methods Population This study evaluated data from a study of 560 elderly participants who regularly visited a community welfare center, located in the midnorthern part of Seoul, Korea, between 2008 and 2010. During the 3-year study period, 179 participants visited the welfare center only once, 196 visited twice, and 182 visited three times. We obtained J ou rna l o f D ia be tes & M e ta bolism
doi:10.4172/2155-6156.1000434 fatcat:fhjshezimnaktilt74gaksaoiy