Detection of SARS-COV-2 Antibodies in Pediatric Kidney Transplant Patients [post]

Alanoud Alshami, Rabab Alattas, Ahmed Azzam, Amani Mohammed
2021 unpublished
Background The seroprevalance of SARS-COV-2 infection have been studied in immunocompetent children. However, data in pediatric Kidney Transplant population (PKT) is lacking. Methods We screened 72 PKT patients who came for routine blood work in the outpatient clinic using two commercial immunoassays that measures IgG antibodies against SARS-COV-2 spike protein and IgG against the Nucleocapsid protein. Majority of patients with positive serology had their serology test repeated at least once
more » ... ing subsequent clinic follow up. Patients were confirmed to have SARS-COV-2 infection if they only have both tests positive. Results Eight patients out of the 72 screened (11.1%) had positive SARS-COV-2 IgG antibodies in both serological tests. Of those tested positive, 4 had positive SARS-COV-2 PCR before screening. All patients were asymptomatic or had history of mild symptoms. All tested patient had persistently positive antibodies at median follow-up time of 75 days (IQR, 44.5, 86.5). One patient remained to have positive PCR at 75 days and positive serology test at 120 days post infection. conclusion The Serooprevalence of SARS-COV-2 was relatively high (11.1%) in our population. SARS-COV-2 PCR seems to remain positive in PKT population for longer duration than general population. Although, all patients were asymptomatic or mildly symptomatic, they mounted a strong humoral immune response that persisted for few months despite being on triple immunosuppressants. These findings will have positive implications on vaccination efficacy in this group.
doi:10.21203/rs.3.rs-140932/v1 fatcat:ekl37zbwgjeu5g4xzzoi7cuevq