α-Asarone Attenuates Cognitive Deficit in a Pilocarpine-Induced Status Epilepticus Rat Model via a Decrease in the Nuclear Factor-κB Activation and Reduction in Microglia Neuroinflammation

Hui-juan Liu, Xin Lai, Yan Xu, Jing-kun Miao, Chun Li, Jing-ying Liu, Yuan-yuan Hua, Qian Ma, Qixiong Chen
2017 Frontiers in Neurology  
Frontiers in Neurology | www.frontiersin.org December 2017 | Volume 8 | Article 661 pathway of kappa B-alpha [inhibitor kappa B-alpha (IκB-α)] and kappa B-beta (IκB-β) kinase in both the SE rats and in primary cultured microglial cells. conclusion: Taken together, these data demonstrate that α-asarone is a promising neuroprotective agent for the prevention and treatment of microglia-mediated neuroinflammatory conditions including TLE, for which further assessment studies are pertinent.
doi:10.3389/fneur.2017.00661 pmid:29312110 pmcid:PMC5735142 fatcat:jdrlendguzaulfahjjwvfrds24