Topological network measures for drug repositioning

Apurva Badkas, Sébastien De Landtsheer, Thomas Sauter
2020 Briefings in Bioinformatics  
Drug repositioning has received increased attention since the past decade as several blockbuster drugs have come out of repositioning. Computational approaches are significantly contributing to these efforts, of which, network-based methods play a key role. Various structural (topological) network measures have thereby contributed to uncovering unintuitive functional relationships and repositioning candidates in drug-disease and other networks. This review gives a broad overview of the topic,
more » ... d offers perspectives on the application of topological measures for network analysis. It also discusses unexplored measures, and draws attention to a wider scope of application efforts, especially in drug repositioning.
doi:10.1093/bib/bbaa357 pmid:33348366 pmcid:PMC8294518 fatcat:zc2wwglvxbeb3fxxjypukchpzq