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Sequence-Based Prediction of Protein Solubility
2012
Journal of Molecular Biology
In order to investigate the relationship between the thermodynamics and kinetics of protein aggregation, we compared the solubility of proteins with their aggregation rates. We found a significant correlation between these two quantities by considering a database of protein solubility values measured using an in vitro reconstituted translation system containing about 70% of Escherichia coli proteins. The existence of such correlation suggests that the thermodynamic stability of the native
doi:10.1016/j.jmb.2011.12.005
pmid:22172487
fatcat:r3aq7dtghbdt3myv27vxr6wkna