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Effect of colchicine on the depletion and replenishment of cytoplasmic glucocorticoid receptor in rat liver after administration of glucocorticoid
1985
Endocrinologia Japonica
Preserved Fulltext
Pretreatment of rats with colchicine (3mg/kg body weight) modified the time course of depletion of the cytoplasmic binding sites for ali-clexamethasone after administration of prednisolone (0.5 or 1.5mg/kg body weight). Colchicine also decreased the rate of the cytoplasmic receptor replenishment which was confirmed by application of this drug after completion of the cytoplasmic receptor translocation to nuclei (30win after prednisolone injection). Addition of colchicine to the incubation
doi:10.1507/endocrj1954.32.225
pmid:4042987
fatcat:rufa2rzfbndbjkbtc26t42ymfm