Internet Archive Scholar

The effect of trans-resveratrol on the expression of the human DNA-repair associated genes

Fumiaki Uchiumi, Jun Arakawa, Yutaka Takihara, Motohiro Akui, Sayaka Ishibashi, Sei-ichi Tanuma
2016 Integrative Molecular Medicine  

Preserved Fulltext

fulltext thumbnail
Web Archive Capture PDF (491.7 kB)
https://web.archive.org/web/20190430161222/https://oatext.com/pdf/IMM-3-246.pdf

A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL. The file type is application/pdf.

A natural compound Resveratrol (Rsv), which is found in high concentrations in grape skins and red wine, is expected to be a leading drug for elongating the life span and preventing oncogenesis. This compound is reported to have various beneficial effects on health, including the activation of complex I and anti-oxidative stress. We have been focusing on the regulation of the expression of human genes and have analyzed the promoter activities of several genes that encode DNA
more » ... iated protein factors. Notably, the 5'-upstream regions of these genes very frequently contain the duplicated GGAA-motifs that allow HeLa S3 cells to respond to Rsv. In this review, we discuss the molecular mechanism by which Rsv regulates the expression of genes associated with DNA repair. We suggest the possibility of developing new anti-aging/cancer drugs without harmful side effects, based on a new concept of ameliorating or maintaining the cellular NAD + /NADH level. Uchiumi F (2016) The effect of trans-resveratrol on the expression of the human DNA-repair associated genes Volume 3(5): 783-792
doi:10.15761/imm.1000246 fatcat:uytmff6pezf23a64iehxxcc2k4
Open Access
Citation

Fumiaki Uchiumi, Jun Arakawa, Yutaka Takihara, Motohiro Akui, Sayaka Ishibashi, Sei-ichi Tanuma. "The effect of trans-resveratrol on the expression of the human DNA-repair associated genes." Integrative Molecular Medicine 3.5 (2016)