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Neurohumoral changes have recently attracted much attention as a part of the pathogenesis of heart failure. Activation of neurohumoral factors triggers processes resulting in changes of extracellular matrix composition and, thus, development of myocardial fibrosis. This article addresses a number of factors that directly contribute to the development of myocardial fibrosis.doi:10.18087/cardio.2020.6.n773 pmid:32720625 fatcat:mvo6i2xlezbdtbkrjwz4hkioia