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Expression of Functional G Protein-Coupled Receptors in Photoreceptors of TransgenicXenopus laevis†
2005
Biochemistry
G protein-coupled receptors (GPCRs) constitute the largest superfamily of transmembrane signaling proteins; however, the only known GPCR crystal structure is that of rhodopsin. This disparity reflects the difficulty in generating purified GPCR samples of sufficient quantity and quality. Rhodopsin, the light receptor of retinal rod neurons, is produced in large amounts of homogeneous quality in the vertebrate retina. We used transgenic Xenopus laeVis to convert these retina rod cells into
doi:10.1021/bi051386z
pmid:16262251
fatcat:66yxikistrauzbyoojwc57j6o4