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Nano Aptasensor for Protective Antigen Toxin of Anthrax
2010
Analytical Chemistry
We demonstrate a highly sensitive nano aptasensor for anthrax toxin through the detection of its polypeptide entity, protective antigen (PA toxin) using a PA toxin ssDNA aptamer functionalized single-walled carbon nanotubes (SWNTs) device. The aptamer was developed inhouse by capillary electrophoresis systematic evolution of ligands by exponential enrichment (CE-SELEX) and had a dissociation constant (K d ) of 112 nM. The aptasensor displayed a wide dynamic range spanning up to 800 nM with a
doi:10.1021/ac902791q
pmid:20136122
pmcid:PMC2930939
fatcat:erquslenurd6pbi5mlvteqkd7e