Edited1H magnetic resonance spectroscopy in vivo: Methods and metabolites

Ashley D. Harris, Muhammad G. Saleh, Richard A.E. Edden
2017 Magnetic Resonance in Medicine  
The 1 H-MRS spectrum contains information about the concentration of tissue metabolites within a predefined region of interest (a voxel). The conventional spectrum in some cases obscures information about less abundant metabolites due to limited separation and complex splitting of the metabolite peaks. One method to detect these metabolites is to reduce the complexity of the spectrum using editing. This review provides an overview of the one-dimensional editing methods available to interrogate
more » ... hese obscured metabolite peaks. These methods include: sequence optimizations, echo-time averaging, J-difference editing methods (single BASING, dual BASING and MEGA-PRESS), constant-time PRESS and quantum filtering. It then overviews the brain metabolites whose detection can benefit from one or more of these editing approaches, including ascorbic acid, γ-aminobutyric acid (GABA), lactate, aspartate, N-acetyl aspartyl glutamate, 2hydroxyglutarate, glutathione, glutamate, glycine, and serine.
doi:10.1002/mrm.26619 pmid:28150876 pmcid:PMC5352552 fatcat:fic2u6mcjjb5thrrapzs6txclq