As the field of protein structure prediction continues to expand at an exponential rate, the bench-biologist might feel overwhelmed by the sheer range of available applications. This review presents the three main approaches in computational structure prediction from a non-bioinformatician's point of view and makes a selection of tools and servers freely available. These tools are evaluated from several aspects, such as number of citations, ease of usage and quality of the results. Finally, the

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... applications of models generated by computational structure prediction are discussed.