Original Article Glioneuronal tumor with neuropil-like islands: a histological, immunohistochemical, and molecular study of three cases

Kun Yao, Zejun Duan, Jiuzhou Li, Yinqian Wang, Xi Mei, Shouwei Li, Heqian Zhao, Chenxing Wu, Xueling Qi, Tao Fan
2016 Int J Clin Exp Pathol   unpublished
In this study, we report three cases (male, aged 47, 47 and 53 years respectively) of glioneuronal tumors with neuropil-like islands (GTNI). Two of them had a cerebral tumor, and the other had a spinal tumor. For operations , all patients underwent macroscopically total resection. These three patients are in complete remission (at 33, 13 and 12.5 months, respectively) after surgery. Microscopically, the common feature was the presence of synaptophysin positive neuropil-like islands. No tumor
more » ... slands. No tumor had 1p deletion, 19q deletion and EGFR amplification. IDH1 gene mutation and TP53 gene mutation were both found in all cases. 1p/19q intact astrocytomas and oligoastrocy-tomas showed a high incidence of IDH1 mutation. Two of the presented patients (WHOП) who did not receive che-motherapy and radiotherapy after total resection have not showed any sign of recurrence of tumor, with a survival time of more than 33-months and 13-months. In conclusion, our results suggest that complete resection is a key prognostic factor in GTNI patients.