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Cytogenetic analysis in 24 clinically diagnosed cases of anorectal malformation carried out using GTG banding techniques showed trisomy 21, the chromosomal abnormality of Down syndrome in 4 cases. Of the 4 cases, 3 were male children and 1 was female child and the remaining 21 cases had normal karyotype of a male or female. Four cases as were found possessing the karyotype of Down syndrome were phenotypically not having the clinical symptom of a typical Down syndrome. The study has been carrieddoi:10.5897/jmgg11.013 fatcat:vesik2jbl5clte4bih2hv6trie