One of the main challenges in security today is defending against malware attacks. As trends and anecdotal evidence show, preventing these attacks, regardless of their indiscriminate or targeted nature, has proven difficult: intrusions happen and devices get compromised, even at security-conscious organizations. As a consequence, an alternative line of work has focused on detecting and disrupting the individual steps that follow an initial compromise and are essential for the successful

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... ion of the attack. In particular, several approaches and techniques have been proposed to identify the command and control (C&C) channel that a compromised system establishes to communicate with its controller. A major oversight of many of these detection techniques is the design's resilience to evasion attempts by the well-motivated attacker. C&C detection techniques make widespread use of a machine learning (ML) component. Therefore, to analyze the evasion resilience of these detection techniques, we first systematize works in the field of C&C detection and then, using existing models from the literature, go on to systematize attacks against the ML components used in these approaches.