A new anti-inflammatory lignan from Lonicerae Japonicae flos

Ran Yang, Lei Fang, Jia Li, Yong-Qing Zhang
2019 Figshare  
One new lignan, loniceralanside A (1), together with three known compounds (2–4), were purified from Lonicerae Japonicae Flos. Their structures were determined by HR-ESI-MS, 1 D and 2 D NMR data. Compounds 2–4 were separated from the plant for the first time. The biological test showed that compound 1 had significant anti-inflammatory activity with inhibiting the release of β-glucuronidase induced by platelet-activating factor (PAF) in rat polymorphonuclear leukocytes (PMNs) (IC50 = 3.05 µM).
doi:10.6084/m9.figshare.7846553.v1 fatcat:xesyrusv7nefto5x3h4bdzcfqe