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To review and discuss the literature on the role of cortical structure and function in migraine. Structural and functional findings suggest that changes in cortical morphology and function contribute to migraine susceptibility by modulating dynamic interactions across cortical and subcortical networks. The involvement of the cortex in migraine is well established for the aura phase with the underlying phenomenon of cortical spreading depolarization, while increasing evidence suggests andoi:10.1177/0333102419840643 pmid:30922081 pmcid:PMC6859601 fatcat:rxdnvtmycrhkjkdanv4bxkeblq