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Motivations Gene trees inferred solely from multiple alignments of homologous sequences often contain weakly supported and uncertain branches. Information for their full resolution may lie in the dependency between gene families and their genomic context. Integrative methods, using species tree information in addition to sequence information, often rely on a computationally intensive tree space search which forecloses an application to large genomic databases.doi:10.1371/journal.pone.0159559 pmid:27513924 pmcid:PMC4981423 fatcat:otdbekpe7ve2veau5jhhqtarsy