Methacrylonitrile-Induced Alterations in Carbohydrate Metabolism in the Rat

Veeraraghavan VASANTHAKUMARI, Sivasithambaram NIRANJALI
1997 Journal of clinical biochemistry and nutrition  
Oral administration of methacrylonitrile to male Wistar rats at a dose of 40 mg/kg body weight/day (LD50, 200 mg/kg body weight/day) for 2 weeks caused an increase in blood glucose levels with a depletion of liver glycogen. An increased rate of glycolysis and enhanced glycogenolysis and gluconeogenesis, along with the activation of the hexose monophosphate pathway shunt, were observed, indicating a significant disturbance in the carbohydrate metabolism.
doi:10.3164/jcbn.22.13 fatcat:qvdc6kb6hrhopaqwkezc6dkeum