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Formação de adutos exocíclicos com bases de DNA: implicações em mutagênese e carcinogênese
2002
Química Nova
Recebido em 5/7/01; aceito em 28/11/01 EXOCYCLIC DNA ADDUCTS: IMPLICATIONS IN MUTAGENESIS AND CARCINOGENESIS. A number of ring-extended DNA adducts resulting from reaction of a,b-unsaturated aldehydes, or their epoxides, with DNA bases have been characterized in recent years. These adducts can lead to miscoding during DNA replication which, if not repaired, result in mutations that can contribute to cancer development. Recently, the use of ultrasensitive methods allowed the detection of
doi:10.1590/s0100-40422002000500014
fatcat:bnkxic7pxzaipisit44hbmx4vi