Formação de adutos exocíclicos com bases de DNA: implicações em mutagênese e carcinogênese

Ana Paula M. Loureiro, Paolo Di Mascio, Marisa H. G. Medeiros
2002 Química Nova  
Recebido em 5/7/01; aceito em 28/11/01 EXOCYCLIC DNA ADDUCTS: IMPLICATIONS IN MUTAGENESIS AND CARCINOGENESIS. A number of ring-extended DNA adducts resulting from reaction of a,b-unsaturated aldehydes, or their epoxides, with DNA bases have been characterized in recent years. These adducts can lead to miscoding during DNA replication which, if not repaired, result in mutations that can contribute to cancer development. Recently, the use of ultrasensitive methods allowed the detection of
more » ... etection of background levels of etheno DNA adducts in tissues of untreated animals and humans suggesting the existence of endogenous sources of reactive intermediates. In this review, we briefly summarize the recent advances in the chemistry of these DNA lesions.
doi:10.1590/s0100-40422002000500014 fatcat:bnkxic7pxzaipisit44hbmx4vi