Objective: To study the effects of dezocine combined with anesthesia on serum GSH, CAT, MDA, SOD, TNF-α, CRP, IL-6 and T lymphocyte subsets in patients after laparoscopic surgery for colon cancer. Methods: A total of 120 patients with laparoscopic cholecystectomy in our hospital from January 2014 to January 2017 were enrolled in this study. The patients were divided into the control group (n=60) and the treatment group (n=60) randomly. The control group were treated with remifentanil combined

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... esthesia while the treatment group were treated with dezocine combined with anesthesia. The serum GSH, CAT, MDA, SOD, TNF-a, CRP, IL-6 and peripheral blood CD3+, CD4+, CD8+, CD4+/CD8+ of the two groups before and after surgery were compared. Results: There were no significantly differences of the serum GSH, CAT, MDA, SOD of the two groups before surgery. The serum GSH, CAT, and SOD of the two groups after surgery were significantly lower than those before surgery, the serum MDA of the two groups after surgery were significantly higher than that before surgery, and the serum MDA of the treatment group after surgery were significantly better than that of the control group. There were no significantly differences of the serum TNF-α, CRP, IL-6 of the two groups before surgery. The serum TNF-α, CRP, and IL-6 of the two groups after surgery were significantly higher than those before surgery, and these indexes of the treatment group after surgery were significantly lower than those of the control group. There were no significantly differences of the peripheral blood CD3+, CD4+, CD8+ and CD4+/CD8+ of the two groups before surgery. The peripheral blood CD3+, CD4+ and CD4+/CD8+ of the two groups after surgery were significantly lower than those before surgery, the peripheral blood CD8+ of the two groups after surgery were significantly higher than that before surgery, and CD8+ of the treatment group after surgery were significantly better than that of the control group. Conclusions: Dezocine combined with anesthesia can reduce the [...]