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RNA editing, a post-transcriptional process, allows the diversification of proteomes beyond the genomic blueprint; however it is infrequently used among animals. Recent reports suggesting increased levels of RNA editing in squids thus raise the question of their nature and effects in these organisms. We here show that RNA editing is particularly common in behaviorally sophisticated coleoid cephalopods, with tens of thousands of evolutionarily conserved sites. Editing is enriched in the nervousdoi:10.1016/j.cell.2017.03.025 pmid:28388405 pmcid:PMC5499236 fatcat:ok5yr2ql2fbbvlti42zw5d2jve