Bridging Use of Plasma Exchange and Continuous Hemodiafiltration before Living Donor Liver Transplantation in Fulminant Wilson's Disease

Yoshiko NAGATA, Hirofumi UTO, Satoru HASUIKE, Akio IDO, Katsuhiro HAYASHI, Toshiharu ETO, Toshiro HAMAKAWA, Koichi TANAKA, Hirohito TSUBOUCHI
2003 Internal medicine (Tokyo. 1992)  
A 15-year-old girl presented with acute hepatic failure showing ascites and hepatic encephalopathy, accompanied by hemolytic anemia. She was diagnosed as having fulminant Wilson's disease (FWD). Plasma exchange (PE), continuous hemodiafiltration (CHDF) and Dpenicillamine administration were started immediately. Copper [24,000 jig] was removed by PE and CHDFover three days, which relieved the jaundice and the consciousness disorder. A successful liver transplant followed. FWDprogresses rapidly
more » ... d often liver transplantation is the only possible therapy. In this case, PE and CHDFwere an effective therapy bridge until liver transplantation.
doi:10.2169/internalmedicine.42.967 fatcat:zp3hrqmvina6xppcedtvm6djhu