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Wnt receptors, bone mass, and fractures: gene-wide association analysis of LRP5 and LRP6 polymorphisms with replication
2011
European Journal of Endocrinology
ObjectiveGenes explaining the susceptibility to osteoporosis have not been fully elucidated. Our objective was to explore the association of polymorphisms capturing common variations of the lipoprotein receptor-related protein (LRP) 5 and 6 genes, encoding two Wnt receptors, with femoral neck bone mineral density (BMD) and osteoporotic fractures of the spine and the hip.DesignCross-sectional, case–control, and replication genetic association study.MethodsThirty-nine tagging and functional
doi:10.1530/eje-10-0582
pmid:20926594
fatcat:lixcdw23tjd3jettfbyejmzixa