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Summarizing internal dynamics boosts differential analysis and functional interpretation of super enhancers
[article]
2021
bioRxiv
pre-print
Super enhancers (SEs) are broad enhancer domains usually containing multiple constitute enhancers with significantly elevated activities. The constitute enhancers work together through chromatin looping to build up distinct regulatory properties of SEs. Aberrant SE activities, which are critical to understand disease mechanisms, could be raised by the alterations of one or more of their constitute enhancers. However, the state-of-art binary strategy in calling differential SEs only relies on
doi:10.1101/2021.09.25.461810
fatcat:7kltakpofjbb3fdv3znkjbunka