Measurement of Adult Human Brain Responses to Breath-Holding by Multi-Distance Hyperspectral Near-Infrared Spectroscopy

Zahida Guerouah, Steve Lin, Vladislav Toronov
2021 Applied Sciences  
A major limitation of near-infrared spectroscopy (NIRS) is its high sensitivity to the scalp and low sensitivity to the brain of adult humans. In the present work we used multi-distance hyperspectral NIRS (hNIRS) to investigate the optimal source-detector distances, wavelength ranges, and analysis techniques to separate cerebral responses to 30 s breath-holds (BHs) from the responses in the superficial tissue layer in healthy adult humans. We observed significant responses to BHs in the scalp
more » ... modynamics. Cerebral responses to BHs were detected in the cytochrome C oxidase redox (rCCO) at 4 cm without using data from the short-distance channel. Using the data from the 1 cm channel in the two-layer regression algorithm showed that cerebral hemodynamic and rCCO responses also occurred at 3 cm. We found that the waveband 700–900 nm was optimal for the detection of cerebral responses to BHs in adults.
doi:10.3390/app12010371 fatcat:4yopjydhsbf4lcqhs3tbv3w3uy