Evaluating autoimmunity markers (TPO Ab, Tg Ab and TM Ab) in hypothyroid patients of Bushehr province

Iraj Nabipour, Fatemeh Rezapour, Seyed Mojtaba Jafary
2005 Iranian South Medical Journal  
Chronic autoimmune thyroiditis (Hashimoto's Thyroiditis) is the common cause of primary hypothyroidism in iodine sufficient countries. Iran is named an iodine sufficient country, in this century. Methods: A total of 88 hypothyroid patients, on suppressing dose of levothyroxine who were followed in a university endocrine disorder clinic were evaluated for serum thyroid autoimmunity markers: thyroid peroxidase antibody (TPO Ab), thyroglobulin antibody (Tg Ab) and thyroid microsomal antibody (TM
more » ... ) using ELISA method. Results: The prevalence of TPO Ab, Tg Ab and TM Ab were 73.9%, 45.5% and 71.6%, respectively. Among the patients with high level of TPO Ab (> 75 u/ml), 45.3% had grade 1 or 2 of goiter (P< 0.05). Conclusion: Autoimmune thyroid disease (Hashimoto's thyroiditis) is the most common cause of hypothyroidism in Bushehr province.
doaj:238e5b5d12ba46718a60192b0dc294b1 fatcat:6n6yxylqcbhv3ngolcthow257a