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e0521 Clinical evaluation of statin therapy in diabetic patients undergoing percutaneous coronary intervention
2010
Heart
Preserved Fulltext
Results Rapamycin made the expression and activation of KLF2 strongly reduce by 75.6% and 78.2% so as to induce long-term coronary endothelial dysfunction. In HUVECs, rapamycin made basal eNOS and t-PA decrease by 80% and 87.8%, while making basal PAI-1 and TF increase by 2.5 and 1.5-fold. After treatment by statins (especially lovastatin), the expression of KLF2 was increased by 3.8-fold nearly reversing to normal state. Conclusions Taken together, these observations indicate that
doi:10.1136/hrt.2010.208967.521
fatcat:3og7worntbgjjfozarlshpsvva