Histopathology and reorganization of chandelier cells in the human epileptic sclerotic hippocampus

J. I. Arellano
2004 Brain  
the human epileptic hippocampus, GABAergic circuits are more highly modi®ed than previously thought. When considered along with other extrahippocampal alterations, we suggest that these changes are important in the pathophysiology of temporal lobe epilepsy associated with hippocampal sclerosis. Abbreviations: AIS = axon initial segment; CB = calbindin; Ch-terminal: chandelier cell axon terminal; GAT-1 = GABA transporter 1; ir = immunoreactive; NeuN = neuron-speci®c nuclear protein; PSA-NCAM =
more » ... otein; PSA-NCAM = polysialylated neural cell adhesion molecule; PV = parvalbumin granular cell layer and in the CA2 ®eld are relatively unaffected. In addition, there is often a dispersion of the dentate granular cell layer, ectopic neurons being found in the molecular layer (Houser, 1990; Houser et al., 1992) . Neuronal loss is accompanied by axonal reorganization
doi:10.1093/brain/awh004 pmid:14534159 fatcat:k4cu5iofhvdzbngikfdvjvpwuq