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Metastasis Suppressor KISS1 Seems to Reverse the Warburg Effect by Enhancing Mitochondrial Biogenesis
2013
Cancer Research
Cancer cells tend to utilize aerobic glycolysis even under normoxic conditions, commonly called the "Warburg effect." Aerobic glycolysis often directly correlates with malignancy, but its purpose, if any, in metastasis remains unclear. When wild-type KISS1 metastasis suppressor is expressed, aerobic glycolysis decreases and oxidative phosphorylation predominates. However, when KISS1 is missing the secretion signal peptide (DSS), invasion and metastasis are no longer suppressed and cells
doi:10.1158/0008-5472.can-13-1183
pmid:24351292
pmcid:PMC3946400
fatcat:enf33muzpffmddyz7ve7gljnfe