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Construction and evaluation of a novel Bacillus subtilis spores-based enterovirus 71 vaccine
Journal of Applied Biomedicine
Enterovirus 71 (EV71) infection and its associated hand-foot-mouth disease is a significant public health problem. The purpose of this study is to develop a novel vaccine to prevent EV71 infection. Bacillus subtilis spores were engineered to express VP1 protein of EV71 with CotB as carrier protein. The recombination was tested in adult mice for the ability to induce immune responses. Mice were inoculated orally and intranasally simultaneously with the spores. The vaccine's efficacy ondoi:10.2478/v10136-012-0032-9 fatcat:ync6dknmmfdfdcmz73axx26w7q