Amyloid β42Activates a G-Protein-Coupled Chemoattractant Receptor, FPR-Like-1

Yingying Le, Wanghua Gong, H. Lee Tiffany, Alexei Tumanov, Sergei Nedospasov, Weiping Shen, Nancy M. Dunlop, Ji-Liang Gao, Philip M. Murphy, Joost J. Oppenheim, Ji Ming Wang
2001 Journal of Neuroscience  
Amyloid ␤ (A␤) is a major contributor to the pathogenesis of Alzheimer's disease (AD). Although A␤ has been reported to be directly neurotoxic, it also causes indirect neuronal damage by activating mononuclear phagocytes (microglia) that accumulate in and around senile plaques. In this study, we show that the 42 amino acid form of ␤ amyloid peptide, A␤ 42 , is a chemotactic agonist for a seven-transmembrane, G-protein-coupled receptor named FPR-Like-1 (FPRL1), which is expressed on human
more » ... lear phagocytes. Moreover, FPRL1 is expressed at high levels by inflammatory cells infiltrating senile plaques in brain tissues from AD patients. Thus, FPRL1 may mediate inflammation seen in AD and is a potential target for developing therapeutic agents.
doi:10.1523/jneurosci.21-02-j0003.2001 pmid:11160457 fatcat:ues55x7hefeqxa5ecyx2rcggzu