CA3 NMDA receptors are required for experience-dependent shifts in hippocampal activity

Kelly Kent, Kenneth Hess, Susumu Tonegawa, Scott A. Small
<span title="">2007</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="" style="color: black;">Hippocampus</a> </i> &nbsp;
The anatomical distribution of sensory-evoked activity recorded from the hippocampal long-axis can shift depending on prior experience. In accordance with Marr's computational model of hippocampal function, CA3 NMDA receptors have been hypothesized to mediate this experience-dependent shift in hippocampal activity. Here we tested this hypothesis by investigating genetically-modified mice in which CA3 NMDA receptors are selectively knocked-out (CA3-NR1 KO). First, we were required to develop an
more &raquo; ... MRI protocol that can record sensory-evoked activity from the mouse hippocampal long-axis. This goal was achieved in part by using a dedicated mouse scanner to image odor-evoked activity, and by using non-EPI (echo planer imaging) pulse sequences. As in humans, odors were found to evoke a ventralpredominant activation pattern in the mouse hippocampus. More importantly, odor-evoked activity shifted in an experience-dependent manner. Finally, we found that the experience-dependent shift in hippocampal long-axis activity is blocked in CA3-NR1 knock-out mice. These findings establish a cellular mechanism for the plasticity imaged in the hippocampal long-axis, suggesting how experience-dependent modifications of hippocampal activity can contribute to its mnemonic function.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="">doi:10.1002/hipo.20332</a> <a target="_blank" rel="external noopener" href="">pmid:17607765</a> <a target="_blank" rel="external noopener" href="">fatcat:5o625azebjfjvn27hlhmzwdso4</a> </span>
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