Neuroimaging in Lewy body dementia

Tayyabah Yousaf, George Dervenoulas, Polytimi-Eleni Valkimadi, Marios Politis
<span title="2018-05-14">2018</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="" style="color: black;">Journal of Neurology</a> </i> &nbsp;
Lewy body dementia (DLB) is a common form of cognitive impairment, accounting for 30% of dementia cases in ages over 65 years. Early diagnosis of DLB has been challenging; particularly in the context of differentiation with Parkinson's disease dementia and other forms of dementias, such as Alzheimer's disease and rapidly progressive dementias. Current practice involves the use of [ 123 I]FP-CIT-SPECT, [ 18 F]FDG PET and [ 123 I]MIBG molecular imaging to support diagnostic procedures. Structural
more &raquo; ... imaging techniques have an essential role for excluding structural causes, which could lead to a DLBlike phenotype, as well as aiding differential diagnosis through illustrating disease-specific patterns of atrophy. Novel PET molecular imaging modalities, such as amyloid and tau imaging, may provide further insights into DLB pathophysiology and may aid in early diagnosis. A multimodal approach, through combining various established techniques and possibly using novel radioligands, might further aid towards an in-depth understanding of this highly disabling disease. In this review, we will provide an overview of neuroimaging applications in patients with DLB.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="">doi:10.1007/s00415-018-8892-x</a> <a target="_blank" rel="external noopener" href="">pmid:29761296</a> <a target="_blank" rel="external noopener" href="">fatcat:4aaplvy7bjcitcsigarc5rswhi</a> </span>
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