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Does Ethanol Play a Pro-Oxidant Role during Oxidative Stress in the Liver?
2015
Journal of Biosciences and Medicines
Oxidative stress has been implicated in the pathophysiology of liver injury during xenobiotic and alcohol metabolism, ischemia/reperfusion injury. In this study we examined if ethanol acted as a pro-oxidant making cells become more sensitive to tert-butylhydroperoxide (tBH) killing. Cell viability was determined in a rat hepatoma cell line (FTO2B) and rat primary hepatocytes in culture in the presence or absence of ethanol pretreatment. To elucidate the contribution of labile iron, deferoxamine
doi:10.4236/jbm.2015.38001
fatcat:dsdvtxj6sjbmrpvqgszzwwrpdi