Role of Interleukin-6 in the Control of DNA Synthesis of Hepatocytes: Involvement of PKC, p44/42 MAPKs, and PPARδ

Han Na Suh, Sang Hun Lee, Min Young Lee, Yu Jin Lee, Jang Hern Lee, Ho Jae Han
2008 Cellular Physiology and Biochemistry  
Interleukin-6 (IL-6) is a pleiotropic cytokine with a pivotal role in normal hepatic growth and liver regeneration. Therefore, in the present study, we examined the effect of IL-6 on cell proliferation and the related signaling pathways in primary cultured chicken hepatocytes. IL-6 increased the level of [ 3 H]thymidine incorporation in a time (≥ 6 hr)-and a dose (≥ 0.
doi:10.1159/000185551 pmid:19088449 fatcat:yihkdcoeezbmfpvql6zo3tj3xu