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Despite the improvements in drug screening, high levels of drug attrition persist. Although high-throughput screening platforms permit the testing of compound libraries, poor compound efficacy or unexpected organ toxicity are major causes of attrition. Part of the reason for drug failure resides in the models employed, most of which are not representative of normal organ biology. This same problem affects all the major organs during drug development. Hepatotoxicity and cardiotoxicity are twodoi:10.1208/s12248-017-0171-8 pmid:29270863 pmcid:PMC5804345 fatcat:pxdicmsow5glho27ccblnbhys4