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Cell and Nucleus Shape as an Indicator of Tissue Fluidity in Carcinoma
2021
Physical Review X
Tissue, cell, and nucleus morphology change during tumor progression. In 2D confluent cell cultures, different tissue states, such as fluid (unjammed) and solid (jammed), are correlated with cell shapes. These results do not have to apply a priori to three dimensions. Cancer cell motility requires and corresponds to a fluidization of the tumor tissue on the bulk level. Here, we investigate bulk tissue fluidity in 3D and determine how it correlates with cell and nucleus shape. In patient samples
doi:10.1103/physrevx.11.011033
fatcat:uw2ibrls3zefjmxhrtidtiosum