Synthesis and Characterization of Novel 4-(4-(4-(4-Methoxyphenoxy) Phenoxy) Phenyl)-6-Phenylpyrimidine 2-Amine and their Biological Evaluation

Shah Et Al, Mikita Shah, Kartik Vyas, Rajiv Shah, G Jaani, Kiran Nimavat, Shah, Vyas, Shah
2016 J Pharm Sci Bioscientific Res   unpublished
The synthesis of chalcones was carried out by one pot condensation of 1-chloro-(4-tolyloxy) benzene with 1-(4-hydroxylphenyl) ethanone followed by condensation with various aromatic aldehydes. Prepared chalcones were refluxing with guanidine to yields various pyrimidine derivatives. All the prepared compounds were characterized in by 1H NMR, 13C NMR, IR, MASS spectroscopic techniques. Biological evaluation of mention compounds was also made in terms of gram positive bacteria such as
more » ... us aureus, Bacillus megaterium and gram negative bacteria Escherichia coli, Proteus vulgaris.