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Synthesis and Characterization of Novel 4-(4-(4-(4-Methoxyphenoxy) Phenoxy) Phenyl)-6-Phenylpyrimidine 2-Amine and their Biological Evaluation
2016
J Pharm Sci Bioscientific Res
unpublished
Preserved Fulltext
The synthesis of chalcones was carried out by one pot condensation of 1-chloro-(4-tolyloxy) benzene with 1-(4-hydroxylphenyl) ethanone followed by condensation with various aromatic aldehydes. Prepared chalcones were refluxing with guanidine to yields various pyrimidine derivatives. All the prepared compounds were characterized in by 1H NMR, 13C NMR, IR, MASS spectroscopic techniques. Biological evaluation of mention compounds was also made in terms of gram positive bacteria such as
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