Clinical Severity and Rotavirus Vaccination among Children Hospitalized for Acute Gastroenteritis in Belém, Northern Brazil

Maria Cleonice A. Justino, Patrícia Brasil, Erika Abreu, Yllen Miranda, Joana D'Arc P. Mascarenhas, Sylvia F. S. Guerra, Alexandre C. Linhares
2016 Journal of Tropical Pediatrics  
In March 2006, Brazil introduced the monovalent rotavirus (RV) vaccine (Rotarix TM ) into the public sector. This study assessed the severity of rotavirus gastroenteritis (RVGE) according to the vaccination status among hospitalized children. We identified 1023 RVGE episodes among not vaccinated (n ¼ 252), partially vaccinated (n ¼ 156) and fully vaccinated (n ¼ 615) children. Very severe gastroenteritis (scored ! 15) was reported in 16.7, 17.9 and 13.5% of not vaccinated, partially vaccinated
more » ... rtially vaccinated and fully vaccinated children, respectively. There was a trend for a shorter duration of RV diarrhoea among vaccinated children than in not vaccinated children (p ¼ 0.07). A protective effect of vaccination was noted when mean duration of symptoms and hospital stay are analysed, comparing unvaccinated, partially vaccinated and fully vaccinated children (p < 0.05). We showed a vaccination dose effect trend, with fully vaccinated children having less-severe RVGE than not vaccinated and partially vaccinated children. K E Y W O R D S : rotavirus, gastroenteritis, severity, vaccination status.
doi:10.1093/tropej/fmv098 pmid:26884442 fatcat:g4c4kqvtvzbzbncociemikihhm