Tetrahydrofuran amino acid-containing gramicidin S analogues with improved biological profiles

Sudip Pal, Gajendra Singh, Shyam Singh, Jitendra Kumar Tripathi, Jimut Kanti Ghosh, Sudhir Sinha, Ravi Sankar Ampapathi, Tushar Kanti Chakraborty
2015 Organic and biomolecular chemistry  
Replacement of the d-Phe-Pro units of GS with novel C6-Bn-substituted tetrahydrofuran amino acid minimized its cytotoxicity while preserving its antimicrobial activity, with a few analogs showing selective anti-TB activity as well.
doi:10.1039/c5ob00622h pmid:26008215 fatcat:klbjtmom65ei5pibyod2uie45m