The Evolving Landscape of PD-1/PD-L1 Pathway in Head and Neck Cancer

Xin-Wei Qiao, Jian Jiang, Xin Pang, Mei-Chang Huang, Ya-Jie Tang, Xin-Hua Liang, Ya-Ling Tang
2020 Frontiers in Immunology  
Over the past 10 years, cancer immunotherapy has made significant progress in multiple cancer types and has been gradually been applied to clinical cancer care, in which the programmed cell death protein-1 (PD-1)/programmed cell death ligand 1 (PD-L1) pathway is one of the most attractive targets. Compared with traditional therapies, the emerging PD-1/PD-L1 blockade immunotherapy exhibited more satisfactory curative effects and lower toxicity for patients with advanced head and neck squamous
more » ... l carcinoma (HNSCC). This review analyzes the expression characteristics and clinical significance of PD-1/PD-L1 in HNSCC, the immunosuppressive roles of tumor cell and stromal cell expressing PD-1/PD-L1 in this disease, and presents the development landscape of PD-1/PD-L1 inhibitors, which may provide new curative alternatives for recurrent or metastatic HNSCC.
doi:10.3389/fimmu.2020.01721 pmid:33072064 pmcid:PMC7531035 fatcat:q763w3bmszbclkoemqrjlinxbu