Association of BAFF/BAFF-R Single Nuclear Polymorphisms with Renal Graft Function in Kidney Transplant Recipients [post]

Haiyan Xu, Chenlu Jia, Xiaozhou He, Renfang Xu
2022 unpublished
The BAFF/BAFF-R signal correlates with antibody-mediated rejection and renal function decline after renal transplantation. We investigated the relationship between BAFF/BAFF-R single nucleotide polymorphisms (SNPs) and renal graft function in kidney transplant recipients. Kidney transplant recipients (310) along with randomly selected healthy control individuals (51) were followed from September 2020 to March 2021 in Third Affiliated Hospital of Soochow University. Anticoagulated peripheral
more » ... d and serum were collected from all individuals. Five BAFF/BAFF-R SNPs were genotyped by TaqMan quantitative PCR. According to the estimated glomerular filtration rate (eGFR) cut-off value of 90 mL·min-1·1.73 (m2)-1, the recipients were divided into normal and abnormal eGFR groups. Analysis results revealed that BAFF rs9514828 CT genotype carriers had a significantly higher incidence of abnormal graft kidney function than other genotype carriers (OR = 1.597, 95% CI = 1.012–2.519, P < 0.05) and had no significant correlation with serum soluble BAFF level and positive rate of panel reactive antibodies; There was a strong linkage disequilibrium between the BAFF rs16972194, rs9514828, and rs16972197; Recipients woth haploid GCG had a significantly higher incidence of normal graft function (OR = 0.381, 95% CI = 0.156–0.931, P < 0.05). This present results suggest that BAFF rs9514828 CT genotype may be a risk factor for kidney transplant recipients, resulting in reduced graft function, whereas the GCG haploid may play a protective role in normal graft function.
doi:10.21203/ fatcat:c3oohlo2hrcxfeq7bq6em2623m