Human development is influenced by genetic, environmental, and social factors whose foundation is formed from infancy and childhood. Preterm birth and low birth weight are important issues that can affect the development and threaten the public health. Objectives: The aim of this study was to evaluate and compare motor development manipulation, balance, aiming, and receiving in low, very low birth weight, and normal children aged 3 to7 years. Methods: In this comparative study, 63 children were

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... selected from among the preterm infants admitted to NICU ward. They were divided into three groups of (1) low birth weight children (mean 2066 ± 354 g) (n = 30), (2) very low birth weight children (mean 1325 ± 117 g) (n = 13), and (3) preterm twin children (mean 1781 ± 385 g) (n = 20).Also, 15 term children with an average weight (3345 ± 365 g) were selected. To evaluate the motor development of children, the Movement Assessment Battery for Children (Second Edition) (MABC-2) test was used. The results were analyzed by SPSS using one-way ANOVA test (P ≤ 0.05). Results: Low birthweight and very low birthweight children had poorer performance on manipulation, aiming, catching, and balance compared to normal children (P ≤ 0.05). Conclusions: VLBW children performed significantly poorer than LBW and Twin children on the subscales of posting coins, threading beads, drawing trail, one-leg balance, and walking heels raised.